Do not Lower, split, crush, chew, or try and dissolve OxyContin as this could impair the managed-release shipping system and may end in a possibly deadly dose of oxycodone. OxyContin might induce sedation which can impair your response competencies and have an impact on your ability to push or operate machinery.
Just after halting a CYP3A4 inducer, as the results on the inducer decrease, the oxycodone plasma concentration will improve [see Scientific PHARMACOLOGY], which could increase or lengthen both equally the therapeutic consequences and adverse reactions and could result in really serious respiratory depression.
A analyze of OXYCONTIN in clients with hepatic impairment shown higher plasma concentrations than These noticed at equal doses in folks with ordinary hepatic perform [see CLINICAL PHARMACOLOGY].
Safety has not been founded in kids beneath age 18; warning or avoidance is suggested in Expecting and breastfeeding Gals as infants could be born with opioid tolerance and frustrated respirations. Moreover, very low concentrations of Oxycontin happen to be found in breast milk.
There exists a partnership among rising oxycodone plasma focus and expanding frequency of dose-linked opioid adverse reactions for example nausea, vomiting, CNS outcomes, and respiratory depression.
Ask your medical professional or pharmacist if you need to have naloxone accessible to treat opioid overdose. Teach Your loved ones or household members with regards to the signs of an opioid overdose and how to deal with it.
Due to the pitfalls connected with accidental ingestion, misuse, and abuse, advise sufferers to retail store OXYCONTIN securely, from sight and arrive at of kids, As well as in a location not available by Other people, together with guests to the home.
The conversion elements Within this desk are only for the conversion from one of the outlined oral opioid analgesics to OXYCONTIN.
opioid receptor, although it may possibly bind to other opioid receptors at larger dosages. Oxycodone is an entire agonist within the mu
OXYCONTIN is contraindicated in sufferers with identified or suspected gastrointestinal obstruction, together with paralytic ileus.
Teach people and caregivers on how to acknowledge respiratory melancholy and emphasize the significance of contacting 911 or having unexpected emergency health care support instantly inside the event of the regarded or suspected overdose.
Accidental ingestion of even 1 dose, particularly in little ones, may result in a fatal overdose of oxycodone.
OXYCONTIN is formulated with inactive substances meant to make the pill click here more challenging to govern for misuse and abuse. For the purposes of describing the outcomes of studies with the abuse-deterrent qualities of OXYCONTIN resulting from a modify in formulation, With this portion, the initial formulation of OXYCONTIN, and that is no more marketed, is going to be referred to as “original OxyContin” as well as reformulated, presently promoted product or service might be often called “OXYCONTIN".
Opioids are sought for nonmedical use and are issue to diversion read more from legitimate prescribed use. Take into account these challenges when prescribing more info or dispensing OXYCONTIN. Procedures to lower these threats include prescribing the drug in the smallest appropriate quantity and advising the patient on very careful storage with the drug in the course of the training course of treatment and the correct disposal of unused drug.